I would say yes it is quite different. From the people I know who have owned them and according to Colt, the reason the Delta Elite was taken off the market is they had a tendency to beat themselves to death.
The 1911 in 45 ACP has been around long enough and has enough of a track record that there is little doubt it will hold up to many years of shooting.
Consider the working pressure of the two cartridges and this becomes easier to understand. The 10mm operates at an industry standard of 37,500 psi. The 45 ACP operates at something more like 18,000 psi.
The 45 ACP is a low intensity cartridge and consequently is much easier on the guns it is fired in. The 10mm operates at slightly higher pressure than the 357 Mag.
Hope this helps.