Not the best platform to build an IPSC open class, at least in the context of winning..but that is another discussion. As far as the caliber in that gun, there should not be any problems. There are a few people around that use the Glock to race and they seem to work. I shot 9x21 out of a modified springfield armory P9 with a lot of success. The round loaded easily and I was able to shoot a variety of loads ranging from 150gr RN bullet to 115 JHPs all at 180PF. I would suggest you have a chronograph when working your loads up and watch very carefully for pressure signs as you are working with a very small case capacity. I believe Vihtavori lists load info for 9x21 on there website, fiochi makes ammo too. Good luck, have fun