Back in 90, 91 while on assignment in South Africa I carried a custom .45 Winchester Magnum 1911 with a carry comp fitted by Austin Behlert.
The gun started life as a blued LAR Grizzly 6.5" .45 Win Magnum and Austin reduced the slide length to 4" then welded/blended his excellent comp to the slide for a very clean and seamless 5.25" installation.
I also had him round the trigger guard and work the frame profile to allow for use in most 1911 holsters, I had a friend at the PA Rifle work up a load using the excellent Hornandy 270gr FP FMJ at 1,300fps that would print into 3" @ 25 yards (I know this is not great by today's standards but this was a comped .45 WM).
I went to the .45 Win Magnum at the time due to relatively “poor” results from the .45acp. We were restricted to using FMJ/non-expanding ammo at the time and issued/restricted to concealed carry of handguns 1911s in this case.
(Let me explain, the .45 acp was working but not quickly enough, on one occasion I stitched an individual four times in the center mass/chest and he responded by shredding the wall I was leaning (hiding) against with about 20 rds of 7.62mm.
I quickly ran out of ammo as their numbers were overwhelming and with only three men on our team we were taking far too much return fire during the confrontation and the rifle rounds destroyed every piece of decent cover available in the residence.
I learned a new respect for the 7.62mm’s penetration capabilities, as those rounds seemed to shoot through everything. The .45acp did prove fatal and they lost seven men and I am quite sure that at least 4 were seriously wounded, but these guys were not going down fast enough and flat out I am not a good enough shot to make head shots while I am running for my life, if you can more power to you.)
I had purchased the Grizzly before the trip/move for defensive use against large animals while in SA (I actually never needed it for "animals" of the 4 legged variety). After the first few failures/confrontations I searched for at least one 10mm, I did find multiple .38 Supers but I knew we needed to pack as much power under the sport coats as possible.
Without authorization for automatic weapons, even shotguns would have been preferred I could not locate one in time so the custom .45WM went into service.
(The restriction to handguns was due mainly to the fact that our principle was a public figure with his own news correspondent and staff photographer and he refused all authorizations for heavy weapons/carbines, JHP ammo. He was a staunch anti-gun supporter and he followed the regulations of his govt. to the letter. (Funny thing is how much his views have changed. After being reassigned, he moved to Northern Ireland as a special prosecutor until 1997 then relocated to NY and opened a string of “Irish” restaurants in Phila, PA. Cincinatti, Ohio. and NYC. One confrontation in his restaurant lead to four men “appearing” in his home during dinner with his family. He called in my team and we were able to resolve the issues that were hindering his new business venture and we trained two full time security personnel for his family.
Last year he graduated from Gunsite’s 250 course and he has begun to see the “merit” in civilian ownership of personal firearms.)
Using only a handgun against guerrillas/home pirates and poachers armed with .308 G3s and Galils was not "big" on my list but the .45 Win Magnum proved to be very effective and controllable with the comp.
The comps only disadvantage was the fireball that came out of the dual ports but the Behlert angle kept the massive .45 WM gases held nicely about 12" above the front sight.
When using a comp to increase the “power” factor or the controllability I believe that if the gun is properly designed and built the comp can be a huge asset with relatively minor drawbacks.
If the comp works well for you and is designed for your methods of carry I would say absolutely, use it and enjoy it.