Well, I've kind of got the big bores out of my system now, but I think you should take one of two directions: traditional with a .45-70 or the best early modern medium, the .375 H&H.
A .45-70 will push a 400 grain bullet over 2000 fps in a strong modern rifle like a Ruger (but that 7.5 lb rifle does kick) and the .375 will move a 270 out at an easy 2750 fps; about the same as a 180 grain .30-'06.
Everybody makes a rifle in one or the other of those calibers, components and dies are standard catalog items, and there are reams of loading data in print.
There are lots of other medium to large bores out there, but I think these are the ones to look at to start with.
A .45-70 will push a 400 grain bullet over 2000 fps in a strong modern rifle like a Ruger (but that 7.5 lb rifle does kick) and the .375 will move a 270 out at an easy 2750 fps; about the same as a 180 grain .30-'06.
Everybody makes a rifle in one or the other of those calibers, components and dies are standard catalog items, and there are reams of loading data in print.
There are lots of other medium to large bores out there, but I think these are the ones to look at to start with.