I have used some of these heavy bullets successfully in a Volunteer Arms Commando 45 using Unique and 2400 powders and sized to .452.
Just wondering if there are any problems using them in a Colt Govt or similar handgun using a heavy recoil spring.
In an article "Taffin Tests..the .45 ACP" in American Handgunner Nov/Dec 1988, John Taffin implies that all the loads presented could be used in the self-loaders. However, test loads for the 250gr Keith bullets were fired from a 6" S&W revolver.
Max loads he suggested for 250gr Keith were 2400 15.0gr; Unique 7.5gr.